Geier Johannes, Frosch Peter J, Schnuch Axel, Agathos Monika, Bauer Andrea, Brasch Jochen, Gaber Gisela, Gottlöber Petra, Grabbe Jürgen, Hartmann Martin, Jappe U T A, Kaatz Martin, Lübbe Dieter, Pirker Claudia, Gefeller Olaf
Information Network of Department of Dermatology, University of Göttingen, Germany.
Contact Dermatitis. 2002 May;46(5):258-61. doi: 10.1034/j.1600-0536.2002.460502.x.
Thiuram mix is tested in the standard series at a test concentration of 1% pet. The single thiurams (DPTD, TMTD, TMTM, TETD), however, are usually tested at 0.25% pet. in Germany. In other countries, the individual components of thiuram mix are tested at 1% pet. The German Contact Dermatitis Research Group (DKG) compared both patch test concentrations in 530 patients in order to find out if (i) a significant number of positive patch tests are missed by testing at the lower concentration, (ii) problems with irritant test reactions occur by increasing the test concentration to 1%, and (iii) the sensitivity of the thiuram mix rises when the breakdown test is done with the higher concentration. Slightly more positive reactions were seen with the higher concentration, but this increase did not reach statistical significance. The reaction index, as a measure for the relation of positive to irritant and/or questionable reactions, remained unchanged for the individual thiurams. The sensitivity of the mix also did not change when the breakdown test was performed with 1% pet. instead of 0.25% pet. Thus, we conclude that both concentrations are of equal diagnostic value in patch testing.
福美双混合物在标准系列中以1%（石油醚）的测试浓度进行测试。然而，在德国，单一福美双（二丙基二硫代氨基甲酸锌、福美双、一硫化四甲基秋兰姆、二硫化四乙基秋兰姆）通常以0.25%（石油醚）的浓度进行测试。在其他国家，福美双混合物的各个成分以1%（石油醚）的浓度进行测试。德国接触性皮炎研究小组（DKG）对530名患者的两种斑贴试验浓度进行了比较，以确定：（i）较低浓度测试是否会遗漏大量阳性斑贴试验；（ii）将测试浓度提高到1%是否会出现刺激性试验反应问题；（iii）使用较高浓度进行分解试验时，福美双混合物的敏感性是否会提高。较高浓度时出现的阳性反应略多，但这种增加未达到统计学显著性。作为阳性与刺激性和/或可疑反应关系度量的反应指数，对于单一福美双而言保持不变。当以1%（石油醚）而非0.25%（石油醚）进行分解试验时，混合物的敏感性也没有变化。因此，我们得出结论，两种浓度在斑贴试验中具有同等的诊断价值。
