Guillem François, Bicu Monica, Semkovska Maria, Debruille J Bruno
Centre de Recherche Fernand-Seguin, Hôpital L-H Lafontaine, 7331 Rue Hochelaga, Montréal, Québec, H1N 3V2, Canada.
Schizophr Res. 2002 Jul 1;56(1-2):137-47. doi: 10.1016/s0920-9964(01)00257-2.
Recent studies suggest that personality may influence symptom expression and social functioning in schizophrenia. This study investigated the relationships between personality and symptom dimensions in schizophrenia patients. Fifty-two schizophrenia patients and 25 five healthy subjects were assessed using the Temperament and Character Inventory (TCI). The patients were also assessed for positive and negative symptoms using SAPS and SANS and scored according to Andreasen's (1995: Andreasen, N.C., Arndt, S., Alliger, R., Miller, D., Flaum, M. 1995. Symptoms of schizophrenia. Methods, meanings, and mechanisms. Arch. Gen. Psychiatry, 52, 341-351) classical three dimensional model and by the five dimensional model of Toomey et al. (1997: Toomey, R., Kremen, W.S., Simpson J.C., Samson, J.A., Seidman, L.J., Lyons, M.J., Faraone, S.V., Tsuang, M.T. 1997. Revisiting the factor structure for positive and negative symptoms: evidence from a large heterogeneous group of psychiatric patients. Am. J. Psychiatry, 154, 371-377). Comparisons between patients and controls revealed significant differences on various TCI scores consistent with a global disorganization of personality in schizophrenia involving both basic neurophysiological and potentially genetically determined traits (i.e. temperament) and developmental aspects of personality (i.e. character). Correlation analysis showed distinct associations between symptoms and personality dimensions. The results suggest that the negative and disorganized dimensions of schizophrenia are related temperamental factors, whereas the psychotic symptoms are more related to characterological abnormalities. The observed patterns of associations also underline the heterogeneity of the classical negative and positive dimensions of schizophrenia.
近期研究表明，人格可能会影响精神分裂症的症状表现及社会功能。本研究调查了精神分裂症患者人格与症状维度之间的关系。采用气质和性格量表（TCI）对52名精神分裂症患者和25名健康受试者进行了评估。还使用阳性和阴性症状评定量表（SAPS）及阴性症状评定量表（SANS）对患者的阳性和阴性症状进行了评估，并根据安德烈亚森（1995年：安德烈亚森，N.C.，阿恩特，S.，阿利杰，R.，米勒，D.，弗洛姆，M. 1995. 精神分裂症的症状。方法、意义及机制。《普通精神病学文献》，52，341 - 351）的经典三维模型以及图米等人（1997年：图米，R.，克雷门，W.S.，辛普森，J.C.，萨姆森，J.A.，塞德曼，L.J.，莱昂斯，M.J.，法拉奥内，S.V.，苏恩，M.T. 1997. 重新审视阳性和阴性症状的因子结构：来自一大组异质性精神科患者的证据。《美国精神病学杂志》，154，371 - 377）的五维模型进行评分。患者与对照组之间的比较显示，在TCI各项得分上存在显著差异，这与精神分裂症患者人格的整体紊乱相符，这种紊乱涉及基本神经生理以及潜在的遗传决定特质（即气质）和人格的发展方面（即性格）。相关分析显示症状与人格维度之间存在明显关联。结果表明，精神分裂症的阴性和紊乱维度与气质因素相关，而精神病性症状与性格异常的关系更为密切。所观察到的关联模式也突显了精神分裂症经典阴性和阳性维度的异质性。
