Ono Kenjiro, Komai Kiyonobu, Yamada Masahito
Department of Neurology and Neurobiology of Aging, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.
J Neurol Sci. 2002 Jul 15;199(1-2):93-6. doi: 10.1016/s0022-510x(02)00111-9.
We report a 17-year-old man showing myoclonic involuntary movement (IVM) associated with chronic manganese (Mn) poisoning. The patient, a welder, showed myoclonic IVM mainly in the right upper and lower extremities, elevated levels of Mn in the blood and hair and high-intensity signals in the globus pallidus on T1-weighted MR images. Chelation therapy resulted in improvement of the myoclonic IVM and MRI abnormalities. This is the first report of Mn poisoning characterized by myoclonic IVM without parkinsonism.
