Myoclonic involuntary movement associated with chronic manganese poisoning.

作者信息

Ono Kenjiro, Komai Kiyonobu, Yamada Masahito

机构信息

Department of Neurology and Neurobiology of Aging, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.

出版信息

J Neurol Sci. 2002 Jul 15;199(1-2):93-6. doi: 10.1016/s0022-510x(02)00111-9.

We report a 17-year-old man showing myoclonic involuntary movement (IVM) associated with chronic manganese (Mn) poisoning. The patient, a welder, showed myoclonic IVM mainly in the right upper and lower extremities, elevated levels of Mn in the blood and hair and high-intensity signals in the globus pallidus on T1-weighted MR images. Chelation therapy resulted in improvement of the myoclonic IVM and MRI abnormalities. This is the first report of Mn poisoning characterized by myoclonic IVM without parkinsonism.