Chen Peng, Goldberg David E, Kolb Bryan, Lanser Marc, Benowitz Larry I
Department of Neurosurgery, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9031-6. doi: 10.1073/pnas.132076299.
Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo. We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated areas of the midbrain and spinal cord. This growth was paralleled by improved performance on several behavioral measures.
脑梗死（中风）常常导致功能的严重且不可逆丧失，部分原因是大脑进行解剖学重组的能力有限。此前已表明，嘌呤核苷肌苷可诱导神经元表达一组生长相关蛋白，并在培养和体内实验中促使轴突生长。我们在此表明，在单侧皮质梗死的成年大鼠中，肌苷刺激大脑未受损侧的神经元向中脑和脊髓的失神经支配区域延伸新的投射。这种生长与多项行为指标的改善相平行。
