柠檬黄：一种与过敏反应有关的偶氮染料的固相放射免疫分析研究（偶氮染料与过敏）

Tartrazine: solid-phase radioimmunoassay studies of an azo dye implicated in allergic reactions (azo dyes and allergy).

作者信息

Johnson H M, Smith B G, Kauffman P E

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):278-81. doi: 10.3181/00379727-150-39019.

PMID:1208538

Abstract

A solid-phase radioimmunoassay procedure was adapted for the haptenic study of tartrazine, an azo dye implicated in various forms of allergy. Further, the haptenic relationship of tartrazine and aspirin was investigated, since sensitivity of individuals to the two substances is often clinically associated. The specificity of antibody to tartrazine was directed strongly toward a pyrazolone intermediate of the molecule, 1-(4-sulfophenyl)-3-carboxy-5-hydroxy-pyrazole. Aspirin did not cross-react with anti-tartrazine, suggesting that the clinical association of aspirin and tartrazine sensitivity in patients is a nonimmunological phenomenon.

摘要

一种固相放射免疫分析方法被用于酒石黄（一种与多种过敏形式有关的偶氮染料）的半抗原研究。此外，还研究了酒石黄与阿司匹林的半抗原关系，因为个体对这两种物质的敏感性在临床上常有关联。抗酒石黄抗体的特异性强烈指向该分子的吡唑啉酮中间体，即1-(4-磺苯基)-3-羧基-5-羟基吡唑。阿司匹林与抗酒石黄抗体不发生交叉反应，这表明患者中阿司匹林与酒石黄敏感性的临床关联是一种非免疫现象。