Brown E D, Penhos J C, Recant L, Smith J C
Proc Soc Exp Biol Med. 1975 Dec;150(3):557-60. doi: 10.3181/00379727-150-39077.
Two experiments were conducted to examine the effect of zinc deficiency on glucose tolerance, and on blood and pancreatic insulin concentrations. In the first study, no significant differences in blood glucose or plasma insulin levels were noted between pair-weighted zinc deficient and zinc sufficient rats after an oral glucose load. In the second experiment, the concentration of pancreatic insulin in pair-fed zinc sufficient rats did not differ significantly from that of zinc deficient rats. However, a zinc deficient group fed ad libitum had significantly lower pancreatic insulin levels, suggesting that food restriction may cause increased pancreatic insulin. Thus, zinc deficiency per se had no apparent effect on oral glucose tolerance or pancreatic insulin concentrations.
进行了两项实验以研究锌缺乏对葡萄糖耐量、血液及胰腺胰岛素浓度的影响。在第一项研究中，口服葡萄糖负荷后，配对体重的缺锌大鼠与锌充足大鼠之间的血糖或血浆胰岛素水平未发现显著差异。在第二项实验中，配对喂养的锌充足大鼠的胰腺胰岛素浓度与缺锌大鼠相比无显著差异。然而，自由采食的缺锌组胰腺胰岛素水平显著较低，这表明食物限制可能导致胰腺胰岛素增加。因此，锌缺乏本身对口服葡萄糖耐量或胰腺胰岛素浓度没有明显影响。
