降钙素对实验性伤口DNA合成的影响。
Effect of calcitonin on DNA synthesis in experimental wounds.
作者信息
Lupulescu A
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):703-6. doi: 10.3181/00379727-150-39110.
3H-thymidine incorporation and intracellular distribution in epidermal cells and fibroblasts of scar tissue from wounded rabbits were studied following synthetic salmon calcitonin administration. Both scintillation counting and electron microscopic autoradiography revealed a marked increase in 3H-thymidine incorporation within nuclear dense chromatin of epidermal and fibroblasts cells, mainly in 2-day wounded rabbits and at 2.5 hr. Then, 3H-thymidine uptake decreased moderately. These findings demonstrate an important role of calcitonin on DNA synthesis.
在给予合成鲑鱼降钙素后，研究了受伤兔子瘢痕组织中表皮细胞和成纤维细胞的³H-胸腺嘧啶核苷掺入及细胞内分布情况。闪烁计数和电子显微镜放射自显影均显示，表皮细胞和成纤维细胞核致密染色质内的³H-胸腺嘧啶核苷掺入显著增加，主要见于伤后2天的兔子且在2.5小时时。随后，³H-胸腺嘧啶核苷摄取适度下降。这些发现证明了降钙素在DNA合成中的重要作用。
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