前列腺素对实验性伤口中蛋白质、RNA、DNA及胶原蛋白合成的影响

Effect of prostaglandins on protein, RNA, DNA and collagen synthesis in experimental wounds.

作者信息

Lupulescu A

出版信息

Prostaglandins. 1975 Oct;10(4):573-9. doi: 10.1016/s0090-6980(75)80003-7.

PMID:1197789

Abstract

The effect of exogenous prostaglandins E1, E2 and F2alpha (PGE1, PGE2 and PGF2alpha) on 3H-leucine, 3H-uridine, 3H-thymidine and 3H-proline incorporation in experimental cutaneous wounds has been studied in rats. Prostaglandins E1 and E2 markedly stimulate the incorporation of these tritiated precursors, into protein, RNA, DNA and collagen synthesis, whereas F2 inhibits it. All tested prostaglandins exhibit their maximum effect within the first hours following administration. Most active is PGE1. These observations indicate that application of prostaglandins significantly stimulate incorporation with protein, RNA, DNA and collagen synthesis in the skin of wounded rats and thus, may play a role in epidermal cell growth and division as well as in scar-forming tissue.

摘要

在大鼠身上研究了外源性前列腺素E1、E2和F2α（PGE1、PGE2和PGF2α）对实验性皮肤伤口中3H-亮氨酸、3H-尿苷、3H-胸腺嘧啶核苷和3H-脯氨酸掺入的影响。前列腺素E1和E2显著刺激这些氚化前体掺入蛋白质、RNA、DNA和胶原蛋白合成，而F2则抑制这种掺入。所有测试的前列腺素在给药后的最初几小时内表现出最大效应。最活跃的是PGE1。这些观察结果表明，应用前列腺素可显著刺激受伤大鼠皮肤中蛋白质、RNA、DNA和胶原蛋白的合成掺入，因此可能在表皮细胞生长和分裂以及瘢痕形成组织中发挥作用。