Effects of cholestyramine on 1,2-dimethylhydrazine-induced enteric carcinoma in germfree rats.
作者信息
Asano T, Pollard M, Madsen D C
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):780-5. doi: 10.3181/00379727-150-39124.
PMID:1208598
Abstract
Oral administration of 1,2-dimethylhydrazine (DMH) induced intestinal neoplasms in germfree rats. A supplement of 2% cholestyramine resin in the diet increased the frequency of DMH-induced intestinal tumors and accelerated malignant transformation. Bile acids in the cecal content were determined with and without cholestyramine in order to obtain a correlation between the bile acid metabolism and the enteric carcinogenesis.
摘要
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