Steinman David A
Imaging Research Laboratories, The John P. Robarts Research Institute, The University of Western Ontario, London, Canada.
Ann Biomed Eng. 2002 Apr;30(4):483-97. doi: 10.1114/1.1467679.
Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque. Until recently, our understanding of arterial fluid dynamics and their relationship to atherosclerosis was limited by the use of idealized or averaged artery models. Recent advances in medical imaging, computerized image processing, and computational fluid dynamics (CFD) now make it possible to computationally reconstruct the time-varying, three-dimensional blood flow patterns in anatomically realistic models. In this paper we review progress, made largely within the last five years, towards the routine use of anatomically realistic CFD models, derived from in vivo medical imaging, to elucidate the role of local hemodynamics in the development and progression of atherosclerosis in large arteries. In addition to describing various image-based CFD studies carried out to date, we review the medical imaging and image processing techniques available to acquire the necessary geometric and functional boundary conditions. Issues related to accuracy, precision, and modeling assumptions are also discussed.
局部血流动力学在动脉粥样硬化中是一个重要因素，从早期病变的发展，到中风风险的评估，再到确定成熟斑块的最终命运。直到最近，我们对动脉流体动力学及其与动脉粥样硬化关系的理解还受到理想化或平均动脉模型使用的限制。医学成像、计算机图像处理和计算流体动力学（CFD）的最新进展，现在使得在解剖学上逼真的模型中通过计算重建随时间变化的三维血流模式成为可能。在本文中，我们回顾了主要在过去五年中取得的进展，即朝着常规使用从体内医学成像获得的解剖学上逼真的CFD模型迈进，以阐明局部血流动力学在大动脉粥样硬化发展和进展中的作用。除了描述迄今为止进行的各种基于图像的CFD研究外，我们还回顾了可用于获取必要几何和功能边界条件的医学成像和图像处理技术。还讨论了与准确性、精确性和建模假设相关的问题。
