Humphrey J D, Na S
Department of Biomedical Engineering, Texas A&M University, College Station 77843-3120, USA.
Ann Biomed Eng. 2002 Apr;30(4):509-23. doi: 10.1114/1.1467676.
Recent advances in molecular and cell biology have emphasized the fundamental importance of mechanical factors in regulating the structure and function of cells and extracellular matrix in the vasculature. Consequently, there is an ever-greater motivation to calculate accurately the stress and strain fields in the arterial wall and how they change with disease, injury, and clinical treatment. Although there is an extensive literature on arterial mechanics, our understanding is still far from complete. In this paper, we review some of the salient findings with regard to wall properties, suggest some possible improvements in the calculation of wall stress, and identify some unresolved problems for further research.
分子生物学和细胞生物学的最新进展强调了力学因素在调节血管系统中细胞和细胞外基质的结构与功能方面的根本重要性。因此，人们越来越迫切地想要精确计算动脉壁中的应力和应变场，以及它们如何随疾病、损伤和临床治疗而变化。尽管关于动脉力学已有大量文献，但我们的理解仍远未完善。在本文中，我们回顾了一些关于血管壁特性的显著发现，提出了一些在计算血管壁应力方面可能的改进方法，并指出了一些有待进一步研究解决的问题。
