Bednarska-Makaruk M, Broda G, Kurjata P, Rodo M, Roszczynko M, Rywik S, Wehr H
Institute of Psychiatry and Neurology, Department of Genetics, Warsaw, Poland.
Eur J Epidemiol. 2001;17(8):789-92. doi: 10.1023/a:1015657709060.
Genotype of apolipoprotein E has been identified in a group of randomly selected Polish subjects participating in a cross-sectional study performed within the POL-MONICA Program, the part of international study WHO-MONICA Project. The investigated group consisted of 170 persons, 92 males and 78 females aged 41-69 years (mean age 62.0+/-5.11). The observed frequency of apolipoprotein E alleles was: epsilon2 - 7.6%, epsilon3 - 81.8% and epsilon4 - 10.6%, which was similar to frequencies in the neighbouring European countries. Statistically significant lower means of total cholesterol (TC) and of low density lipoprotein cholesterol (LDL-C) levels in epsilon2 carriers and higher means of TC, of LDL-C and of triglycerides in epsilon4 carriers were observed as compared with noncarriers of respective alleles. Some nonlipid cardiovascular risk factors (hypertension (HT) and obesity) and coronary heart disease (CHD) showed a tendency to lower prevalence in the epsilon2 allele carriers as compared to noncarriers. In the epsilon4 allele carriers a tendency to higher prevalence of HT, but not of CHD was observed as compared to noncarriers of this allele.
在参与POL - MONICA项目（国际研究WHO - MONICA项目的一部分）的一项横断面研究的一组随机选取的波兰受试者中，已鉴定出载脂蛋白E的基因型。被调查的组由170人组成，其中92名男性和78名女性，年龄在41 - 69岁之间（平均年龄62.0±5.11）。观察到的载脂蛋白E等位基因频率为：ε2 - 7.6%，ε3 - 81.8%，ε4 - 10.6%，这与邻近欧洲国家的频率相似。与各自等位基因的非携带者相比，观察到ε2携带者的总胆固醇（TC）和低密度脂蛋白胆固醇（LDL - C）水平的均值在统计学上显著较低，而ε4携带者的TC、LDL - C和甘油三酯的均值较高。与非携带者相比，一些非脂质心血管危险因素（高血压（HT）和肥胖）以及冠心病（CHD）在ε2等位基因携带者中的患病率有降低的趋势。与该等位基因的非携带者相比，在ε4等位基因携带者中观察到HT患病率有升高的趋势，但CHD患病率没有升高趋势。
