性别、灵活性与可变剪接的调控
Sex, AGility, and the regulation of alternative splicing.
作者信息
Graveley Brenton R
机构信息
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington 06030, USA.
出版信息
Cell. 2002 May 17;109(4):409-12. doi: 10.1016/s0092-8674(02)00750-x.
Abstract
Alternative splicing is an important means of regulating the expression of eukaryotic genes and enhancing protein diversity. A detailed examination of the Drosophila Sex-lethal gene has led to two significant discoveries-the role of the splicing factor SPF45 in defining the site of exon ligation, and that alternative splicing can be regulated at the second step.
摘要
可变剪接是调控真核基因表达和增加蛋白质多样性的重要手段。对果蝇性别致死基因的详细研究带来了两项重大发现——剪接因子SPF45在确定外显子连接位点中的作用，以及可变剪接可在第二步受到调控。
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