Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA.
Curr Opin Genet Dev. 2011 Aug;21(4):373-9. doi: 10.1016/j.gde.2011.04.001. Epub 2011 Apr 27.
Alternative splicing is a widespread means of increasing protein diversity and regulating gene expression in eukaryotes. Much progress has been made in understanding the proteins involved in regulating alternative splicing, the sequences they bind to, and how these interactions lead to changes in splicing patterns. However, several recent studies have identified other players involved in regulating alternative splicing. A major theme emerging from these studies is that RNA secondary structures play an under appreciated role in the regulation of alternative splicing. This review provides an overview of the basic aspects of splicing regulation and highlights recent progress in understanding the role of RNA secondary structure in this process.
可变剪接是真核生物增加蛋白质多样性和调控基因表达的一种广泛手段。在理解参与调控可变剪接的蛋白质、它们结合的序列以及这些相互作用如何导致剪接模式变化方面已经取得了很大进展。然而，最近的几项研究已经鉴定出其他参与调控可变剪接的因子。这些研究中出现的一个主要主题是 RNA 二级结构在调控可变剪接中起着被低估的作用。本综述提供了剪接调控的基本方面概述，并强调了理解 RNA 二级结构在该过程中的作用的最新进展。
