Moss William J, Monze Mwaka, Ryon Judith J, Quinn Thomas C, Griffin Diane E, Cutts Felicity
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Baltimore, MD 21205-2179, USA.
Clin Infect Dis. 2002 Jul 15;35(2):189-96. doi: 10.1086/341248. Epub 2002 Jun 19.
Measles in persons coinfected with human immunodeficiency virus (HIV) has been reported to be unusual in its presentation and frequently fatal. To determine the effect of HIV coinfection on the clinical features and outcome of measles, a prospective study of hospitalized children with measles was conducted between January 1998 and October 2000 in Lusaka, Zambia. One-sixth (17%) of 546 children hospitalized with laboratory-confirmed measles were coinfected with HIV. One-third of the HIV-infected children hospitalized with confirmed measles were <9 months old, compared with 23% of HIV-uninfected children (P=.03). Few differences in clinical manifestations, complications, or mortality were found between HIV-infected and HIV-uninfected children with measles. HIV-infected children constitute a significant proportion of children hospitalized with measles in countries with high HIV prevalence and are more likely to be younger than the age for routine measles immunization.
据报道，感染人类免疫缺陷病毒（HIV）的人患麻疹时，其症状不同寻常，且往往致命。为了确定合并感染HIV对麻疹临床特征和转归的影响，于1998年1月至2000年10月在赞比亚卢萨卡对住院的麻疹患儿进行了一项前瞻性研究。546名经实验室确诊为麻疹的住院儿童中有六分之一（17%）合并感染了HIV。确诊为麻疹的住院HIV感染儿童中有三分之一年龄小于9个月，而未感染HIV的儿童中这一比例为23%（P = 0.03）。感染HIV和未感染HIV的麻疹患儿在临床表现、并发症或死亡率方面几乎没有差异。在HIV感染率高的国家，感染HIV的儿童在因麻疹住院的儿童中占相当大的比例，而且他们的年龄更可能低于常规麻疹免疫的年龄。
