Núñez María J, Mañá Paula, Liñares David, Riveiro María P, Balboa José, Suárez-Quintanilla Juan, Maracchi Mónica, Méndez Manuel Rey, López José M, Freire-Garabal Manuel
Neuroimmunology Laboratory, Department of Pharmacology, Schools of Medicine and Nursing, University of Santiago de Compostela, 15705, Santiago de Compostela, Spain.
Life Sci. 2002 Jul 19;71(9):1047-57. doi: 10.1016/s0024-3205(02)01796-4.
The effects of music on the immune system and cancer development were evaluated in rodents subjected to sound stress. Animals were exposed daily to broad band noise around midnight and/or music for 5 hours on the following morning. Thymus and spleen cellularity, peripheral T lymphocyte population, the proliferative response of spleen cells to mitogen concanavalin A and natural killer cell activity were calculated in BALB/c mice. Sprague Dawley rats were injected i.v. with Walker 256 carcinosarcoma cells; 8 days later the rats were sacrificed and the number of metastatic nodules on the surface of the lungs was calculated macroscopically. Music reduced the suppressive effects of stress on immune parameters in mice and decreased the enhancing effects of stress on the development of lung metastases provoked by carcinosarcoma cells. Music enhanced the immune parameters and the anti-tumor response in unstressed rodents. Our data at present demonstrates that music can effectively reverse adverse effects of stress on the number and capacities of lymphocytes that are required for an optimal immunological response against cancer in rodents.
在遭受声音应激的啮齿动物中评估了音乐对免疫系统和癌症发展的影响。动物每天在午夜前后暴露于宽带噪声和/或在次日早晨暴露于音乐5小时。计算BALB/c小鼠的胸腺和脾脏细胞数量、外周T淋巴细胞群体、脾脏细胞对促有丝分裂原刀豆球蛋白A的增殖反应以及自然杀伤细胞活性。给Sprague Dawley大鼠静脉注射Walker 256癌肉瘤细胞；8天后处死大鼠，宏观计算肺表面转移结节的数量。音乐减轻了应激对小鼠免疫参数的抑制作用，并降低了应激对癌肉瘤细胞诱发的肺转移发展的增强作用。音乐增强了未受应激的啮齿动物的免疫参数和抗肿瘤反应。我们目前的数据表明，音乐可以有效逆转应激对啮齿动物中针对癌症的最佳免疫反应所需的淋巴细胞数量和能力的不利影响。
