Jones D E, Halbert D R, Demers L M, Fontana J
Prostaglandins. 1975 Dec;10(6):1047-56. doi: 10.1016/s0090-6980(75)80052-9.
A patient with functional primary dysmenorrhea of over two years duration was subjected to the endometrial jet wash technique during the period of active menstrual flow. Prostaglandin F analysis of the jet washings revealed significantly elevated levels during menstruation over normal control levels. Following indomethacin therapy, jet wash prostaglandin F levels were dramatically reduced and the patient became asymptomatic. A cause and effect relationsship between prostaglandin F and dysmenorrhea is suggested by these studied.
