氟比洛芬治疗原发性痛经
Flurbiprofen in the treatment of primary dysmenorrhoea.
作者信息
Krishna U R, Naik S, Mandlekar A, Gupta K C, Kulkarni V N, Sheth U K
出版信息
Br J Clin Pharmacol. 1980 Jun;9(6):605-8. doi: 10.1111/j.1365-2125.1980.tb01087.x.
Abstract
1 In a double-blind crossover study, flurbiprofen produced marked relief of pain which was significantly more than with aspirin and placebo in patients suffering from primary dysmenorrhoea. In contrast, there was no significant difference between the relief of pain obtained with aspirin and placebo. 2 The clinician's overall assessment of efficacy also indicated that flurbiprofen produced better response as compared to aspirin and placebo in these patients with dysmenorrhoea. 3 Both flurbiprofen and aspirin did not produce any apparent adverse effects on blood loss during the menstrual period. 4 In conclusion, the analgesic effect of flurbiprofen seen in this trial establishes the therapeutic usefulness of the drug in the treatment of primary dysmenorrhoea.
摘要
- 在一项双盲交叉研究中，氟比洛芬能显著缓解原发性痛经患者的疼痛，其效果显著优于阿司匹林和安慰剂。相比之下，阿司匹林和安慰剂在缓解疼痛方面没有显著差异。2. 临床医生对疗效的总体评估也表明，在这些痛经患者中，氟比洛芬的反应比阿司匹林和安慰剂更好。3. 氟比洛芬和阿司匹林对经期失血均未产生任何明显的不良影响。4. 总之，本试验中观察到的氟比洛芬的镇痛作用确立了该药物在治疗原发性痛经方面的治疗价值。
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Studies in the involvement of prostaglandins in uterine symptomatology and pathology.前列腺素与子宫症状及病理关系的研究。
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