Lambert G, Brodeur J
Rev Can Biol. 1975 Sep;34(3):121-9.
A study was undertaken to investigate the influence of various hepatic enzyme inducers on the acute toxicity of the organohalogenated insecticide DDT. Adult female rats were pretreated with sodium phenobarbital (50 mg/kg/day during 5 days), 3-methylocholanthrene (20 mg/kg/day during 3 days), and norethandrolone (20 mg/kg/day during 14 days), and were then given 150 mk/kg of DDT per os. Phenobarbital was shown to lower the toxicity of DDT, norethandrolone had the opposite effect, and 3-methylcholanthrene was without any significant effect. After a phenobarbital pretreatment, the cerebral concentration of DDT was lowered, possibly as a result of an increased biotransformation of DDT to DDD in the liver. On the other hand, norethandrolone did not appear to modify the hepatic conversion of DDT to DDD, nor the cerebral concentration of DDT. Further studies are needed to explain the potentiating effect of norethandrolone on the acute toxicity of DDT.
开展了一项研究，以调查各种肝酶诱导剂对有机卤化杀虫剂滴滴涕急性毒性的影响。成年雌性大鼠分别用苯巴比妥钠（5天内每天50毫克/千克）、3-甲基胆蒽（3天内每天20毫克/千克）和炔诺醇（14天内每天20毫克/千克）进行预处理，然后经口给予150毫克/千克的滴滴涕。结果表明，苯巴比妥可降低滴滴涕的毒性，炔诺醇则有相反作用，而3-甲基胆蒽无任何显著影响。经苯巴比妥预处理后，大脑中滴滴涕的浓度降低，这可能是由于肝脏中滴滴涕向滴滴滴的生物转化增加所致。另一方面，炔诺醇似乎并未改变滴滴涕向滴滴滴的肝脏转化，也未改变大脑中滴滴涕的浓度。需要进一步研究来解释炔诺醇对滴滴涕急性毒性的增强作用。
