Lambert G, Brodeur J
Rev Can Biol. 1976 Mar;35(1):33-41.
A study was under-taken to investigate the influence of pretreatments with various hepatic microsomal enzyme inducers on the elimination of DDT residues in rats previously contaminated with p,p' -DDT at 5 mg/kg/day, during 20 days. The following inducers were used : phenobarbital (50 a mg/kg/day, i.p.), 3,4-benzopyrene (20 mg/kg/day, s.c.) and norethandrolone (20 mg/kg/day, s.c.), all given during 14 consecutive days. Each inducer was administered singly or in combination with the other two according to a 2 X 2 X 2 factorial experiment. The animals were then sacrificed for the measurement of p,p' -DDT, p,p' -DDD and p,p' -DDE residues in the blood, brain, abdominal fat, liver and kidneys. The results show that phenobarbital lowers markedly the concentration of total residues in the fat tissue and brain and that norethandrolone brings about a reduction of the residues in the blood, brain and kidneys, but not in the fat tissue. On the opposite, 3,4-benzopyrene produces an increase of the residues in the brain, liver and kidneys. Phenobarbital thus appears to be more efficacious than the other two inducers in facilitating the elimination of DDT residues from the fat tissue. In addition, it appears that under the experimental conditions used during this investigation, the elimination of DDT residues is not further accelerated by combining the inducers one with each other.
进行了一项研究，以调查用各种肝微粒体酶诱导剂预处理对先前以5毫克/千克/天的剂量连续20天接触对，对'-滴滴涕的大鼠体内滴滴涕残留消除的影响。使用了以下诱导剂：苯巴比妥（50毫克/千克/天，腹腔注射）、3,4-苯并芘（20毫克/千克/天，皮下注射）和炔诺酮（20毫克/千克/天，皮下注射），均连续给药14天。根据2×2×2析因实验，每种诱导剂单独给药或与其他两种联合给药。然后处死动物，测量血液、脑、腹部脂肪、肝脏和肾脏中的对，对'-滴滴涕、对，对'-滴滴滴和对，对'-滴滴伊残留量。结果表明，苯巴比妥显著降低了脂肪组织和脑中总残留量的浓度，炔诺酮使血液、脑和肾脏中的残留量减少，但脂肪组织中的残留量未减少。相反，3,4-苯并芘使脑、肝脏和肾脏中的残留量增加。因此，苯巴比妥在促进从脂肪组织中消除滴滴涕残留方面似乎比其他两种诱导剂更有效。此外，在本研究使用的实验条件下，诱导剂相互联合似乎并未进一步加速滴滴涕残留的消除。
