大鼠肝脏将滴滴涕酶解为滴滴滴：细胞色素P-450酶系统的一些诱导剂和抑制剂的作用。 - Suppr

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Enzymatic detoxication of DDT to DDD by rat liver: effects of some inducers and inhibitors of cytochrome P-450 enzyme system.

作者信息

Zaidi S S, Banerjee B D

出版信息

Bull Environ Contam Toxicol. 1987 Mar;38(3):449-55. doi: 10.1007/BF01606613.

DOI:10.1007/BF01606613

PMID:3814869

Abstract

摘要

相似文献

Enzymatic detoxication of DDT to DDD by rat liver: effects of some inducers and inhibitors of cytochrome P-450 enzyme system.大鼠肝脏将滴滴涕酶解为滴滴滴：细胞色素P-450酶系统的一些诱导剂和抑制剂的作用。

Bull Environ Contam Toxicol. 1987 Mar;38(3):449-55. doi: 10.1007/BF01606613.

Possible role of rat liver NADPH cytochrome P-450 reductase in the detoxication of DDT to DDD.大鼠肝脏NADPH细胞色素P-450还原酶在滴滴涕脱毒转化为滴滴滴过程中的可能作用。

Bull Environ Contam Toxicol. 1987 Aug;39(2):327-33. doi: 10.1007/BF01689425.

[The effect of pretreatment with enzyme inducers on the acute toxicity of DDT (1, 1-bis-(p-chlorophenyl)-2,2,2-trichloroethane) in rats].[酶诱导剂预处理对大鼠体内滴滴涕（1,1-双-（对氯苯基）-2,2,2-三氯乙烷）急性毒性的影响]

Rev Can Biol. 1975 Sep;34(3):121-9.

Immunological and enzymatic comparison of hepatic cytochrome P-450 fractions from phenobarbital-, 3-methylcholanthrene-, beta-naphthoflavone- and 2,3,7,8- tetrachlorodibenzo-p-dioxin-treated rats.苯巴比妥、3-甲基胆蒽、β-萘黄酮和2,3,7,8-四氯二苯并对二恶英处理的大鼠肝脏细胞色素P-450组分的免疫学和酶学比较

Biochem Pharmacol. 1983 Jun 1;32(11):1673-82. doi: 10.1016/0006-2952(83)90108-9.

[Influence of various enzyme inductors and combinations of inductors on DDT residue elimination in rats].[各种酶诱导剂及诱导剂组合对大鼠体内滴滴涕残留消除的影响]

Rev Can Biol. 1976 Mar;35(1):33-41.

Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome P-450.

Biochem Pharmacol. 1974 Aug 15;23(16):2305-14. doi: 10.1016/0006-2952(74)90559-0.

Induction of drug metabolism. VI. Effects of phenobarbital and 3-methylcholanthrene administration on N-demethylating enzyme systems of rough and smooth hepatic microsomes.药物代谢的诱导作用。VI. 苯巴比妥和3-甲基胆蒽给药对肝脏粗面和滑面微粒体N-脱甲基酶系统的影响。

Biochem Pharmacol. 1973 May 1;22(9):1037-45. doi: 10.1016/0006-2952(73)90168-8.

Effect of phenobarbital pretreatment on the metabolism of DDT in the rat and the bovine.

Toxicol Appl Pharmacol. 1971 Feb;18(2):457-68. doi: 10.1016/0041-008x(71)90138-4.

Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI.rC and tilorone.干扰素诱导剂聚肌苷酸-聚胞苷酸和泰洛龙对苯巴比妥及3-甲基胆蒽诱导的抗坏血酸合成和肝细胞色素P-450相关单加氧酶系统的抑制作用

Biochem Biophys Res Commun. 1979 Jun 13;88(3):1017-23. doi: 10.1016/0006-291x(79)91510-9.

Phenobarbital treatments lower DDT body burden in rhesus monkeys.苯巴比妥治疗可降低恒河猴体内的滴滴涕负担。

Arch Environ Contam Toxicol. 1981;10(3):263-70. doi: 10.1007/BF01055627.

引用本文的文献

Possible role of rat liver NADPH cytochrome P-450 reductase in the detoxication of DDT to DDD.大鼠肝脏NADPH细胞色素P-450还原酶在滴滴涕脱毒转化为滴滴滴过程中的可能作用。

Bull Environ Contam Toxicol. 1987 Aug;39(2):327-33. doi: 10.1007/BF01689425.

本文引用的文献

METABOLIC PRODUCTS OF P,P'-DDT IN THE RAT.大鼠体内对，对'-滴滴涕的代谢产物

Toxicol Appl Pharmacol. 1964 May;6:321-7. doi: 10.1016/0041-008x(64)90073-0.

THE STIMULATORY EFFECT OF 3-METHYLCHOLANTHRENE ON MICROSOMAL AMINO ACID INCORPORATION AND BENZPYRENE HYDROXYLASE ACTIVITY AND ITS INHIBITION BY ACTINOMYCIN D.3-甲基胆蒽对微粒体氨基酸掺入及苯并芘羟化酶活性的刺激作用及其受放线菌素D的抑制

Biochim Biophys Acta. 1963 Aug 20;72:657-60.

Metyrapone - reduced cytochrome P-450 complex: a specific method for the determination of the phenobarbital inducible form of rat hepatic microsomal cytochrome P-450.甲吡酮还原型细胞色素P - 450复合物：一种测定大鼠肝微粒体细胞色素P - 450苯巴比妥诱导型的特定方法。

Biochem Biophys Res Commun. 1980 Apr 14;93(3):776-81. doi: 10.1016/0006-291x(80)91144-4.

Metabolism of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane in the mouse.1,1,1-三氯-2,2-双（对氯苯基）乙烷和1,1-二氯-2,2-双（对氯苯基）乙烷在小鼠体内的代谢

Chem Biol Interact. 1982 Sep;41(3):327-39. doi: 10.1016/0009-2797(82)90109-0.

The mechanism of reductive dehalogenation of halothane by liver cytochrome P450.肝脏细胞色素P450对氟烷进行还原脱卤的机制。

Biochem Pharmacol. 1982 Feb 1;31(3):383-90. doi: 10.1016/0006-2952(82)90186-1.

Metabolism-dependent binding of the chlorinated insecticide DDT and its metabolite, DDD, to microsomal protein and lipids.氯化杀虫剂滴滴涕（DDT）及其代谢产物滴滴滴（DDD）与微粒体蛋白和脂质的代谢依赖性结合。

Biochem Pharmacol. 1984 Jan 15;33(2):255-60. doi: 10.1016/0006-2952(84)90483-0.

Dechlorination of DDT in frozen blood.冷冻血液中滴滴涕的脱氯作用。

Science. 1967 May 5;156(3775):663-5. doi: 10.1126/science.156.3775.663.

In vitro metabolism of p,p'DDT in pigeon liver.鸽子肝脏中对，对'-滴滴涕的体外代谢

Nature. 1966 Jun 4;210(5040):1048-9. doi: 10.1038/2101048a0.

Cytochrome P-450 of liver microsomes--one pigment or many.

Biochem Biophys Res Commun. 1968 Mar 27;30(6):607-12. doi: 10.1016/0006-291x(68)90555-x.

Existence and separation of three forms of cytochrome P-450 from rat liver microsomes.

J Biol Chem. 1973 Jul 25;248(14):4947-55.

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