Drewa Tomasz, Olszewska Dorota, Woźniak Alina
Katedra i Zakład Biologii AM w Bydgoszczy.
Pol Merkur Lekarski. 2002 Apr;12(70):336-41.
The distempers considering cell dying have an important meaning in pathogenesis of different diseases, just like the proliferation distempers. Proliferation and dying are probably responsible for homeostasis support at the same part. Two groups of distempers were distinguished. One of them is connected with an increased cell viability (some cancers, autoimmunological diseases, viral infections) and the other where there is an increased cell mortality (AIDS, some neurodegenerative diseases, myelodysplastic syndromes, osteoporosis and others). Programmed cell death induction using gene therapy methods is tested in preclinical examinations. The results of these tests are thought to have an important significance in therapy of many diseases.
考虑细胞死亡的紊乱在不同疾病的发病机制中具有重要意义，就如同增殖紊乱一样。增殖和死亡可能共同维持同一部位的内环境稳定。区分出了两组紊乱。其中一组与细胞活力增加有关（某些癌症、自身免疫性疾病、病毒感染），另一组则是细胞死亡率增加（艾滋病、某些神经退行性疾病、骨髓增生异常综合征、骨质疏松症等）。在临床前检查中测试了使用基因治疗方法诱导程序性细胞死亡。这些测试结果被认为在许多疾病的治疗中具有重要意义。
