Dobryszycka W
Katedra Biochemii Farmaceutycznej Akademii Medycznej, Wrocławiu.
Postepy Hig Med Dosw. 1998;52(5):423-44.
In multicellular organisms homeostasis depends on a balance between cell proliferation and cell death. In this review principles of the physiology of programmed cell death (apoptosis), i.e. biochemical features, involved genes and proteolytic enzymes, are described. Alterations in apoptosis contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, inflammation, hematopoietic and immunological system defects (e.g. AIDS), neurodegenerative disorders. Specific effect on regulation of apoptosis might lead to new possibilities for treatment. Methods of quantitative determinations of apoptosis are discussed.
在多细胞生物体中，稳态取决于细胞增殖与细胞死亡之间的平衡。在本综述中，描述了程序性细胞死亡（凋亡）的生理学原理，即生化特征、相关基因和蛋白水解酶。凋亡的改变促成了许多人类疾病的发病机制，包括癌症、病毒感染、炎症、造血和免疫系统缺陷（如艾滋病）、神经退行性疾病。对凋亡调节的特异性作用可能带来新的治疗可能性。文中讨论了凋亡定量测定的方法。
