[乳腺良性增生（纤维囊性乳腺病）与乳腺癌发生之间的关系]

[The relationship between benign breast proliferation (fibrocystic mastopathy) and the appearance of breast carcinoma].

作者信息

Alexa O, Stolnicu S, Horváth E, Jung J

机构信息

Departamentul de Anatomie Patologică, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Tg. Mureş.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2000 Oct-Dec;104(4):101-9.

PMID:12089936

Abstract

Fibrocystic mastopathy (FM), a benign lesion, is considered by many author like a premalignant lesion. Breast carcinoma (CA) represents the most frequent female tumor and the second mortality cause through cancer, after the bronchopulmonary cancer. At the Department of Pathology from Tg. Mureş, we selected 190 cases, for 10 month: 102 presented FM, 41 CA and 47 CA + FM. In every case, we have examined 2 slides stained with HE. In difficult cases, we performed special stains (van Gieson, H-PAS, Alcian). We studied the pulmonary tumor, adjacent mammary tissue and axillary lymph nodes. The present data of literature and the experience of the Department of Pathology from Tg. Mureş showed a strong relationship between the presence of FM and the appearance of CA: both lesions have a common field of hormonal disfunction and intraductal and intralobular hyperplasia (an microscopic feature of mastopathy) increase the risk of CA.

摘要

纤维囊性乳腺病（FM）是一种良性病变，但许多作者认为它是一种癌前病变。乳腺癌（CA）是女性最常见的肿瘤，也是继支气管肺癌之后癌症导致死亡的第二大原因。在特尔古穆列什病理科，我们在10个月内选取了190个病例：102例为纤维囊性乳腺病，41例为乳腺癌，47例为乳腺癌合并纤维囊性乳腺病。在每个病例中，我们检查了2张苏木精-伊红（HE）染色切片。在疑难病例中，我们进行了特殊染色（范吉森染色、高碘酸-希夫染色、阿尔辛蓝染色）。我们研究了肺部肿瘤、乳腺相邻组织和腋窝淋巴结。现有文献资料以及特尔古穆列什病理科的经验表明，纤维囊性乳腺病的存在与乳腺癌的发生之间存在密切关系：这两种病变都有一个共同的激素功能障碍领域，并且导管内和小叶内增生（乳腺病的一种微观特征）会增加患乳腺癌的风险。