Habor V, Habor A, Copotoiu C, Panţîru A
Clinica Chirurgie I, Spitalul Clinic Judeţean de Urgency, Târgu-Mureş.
Chirurgia (Bucur). 2010 Mar-Apr;105(2):191-4.
Fibrocystic breast disease has developed a major issue: the breast cancer sequence. Its involvement regarding the increse of breast cancer risk has 2 aspects: it may be either the marker of a prone tissue or a premalignant hystological deffect. Difficult differential diagnosis of benign proliferative breast lession and carcinoma led to the idea of sequency between the two: cancer does not initiate on normal mammary epithelia; it takes several proliferative stages for it to occur. In our series we analized a number of 677 breast surgical procedures where the pathologic examination reveals 115 cases (17%) of coexistence between cancer and fibrocystic breast disease. This aspect has proved to be related to earlier debut of breast cancer, suggesting that epithelial hyperplasia is a risk factor for breast cancer.
乳腺癌序列。其与乳腺癌风险增加的关联有两个方面：它可能是易患组织的标志物，也可能是癌前组织学缺陷。良性增生性乳腺病变与癌的鉴别诊断困难，由此产生了两者之间存在序列关系的观点：癌症并非起源于正常乳腺上皮；它需要经过几个增殖阶段才会发生。在我们的系列研究中，我们分析了677例乳腺外科手术病例，其中病理检查显示115例（17%）存在癌症与纤维囊性乳腺病并存的情况。这一情况已被证明与乳腺癌的更早发病有关，表明上皮增生是乳腺癌的一个风险因素。
