Bennett A E, Rathore S, Rhatigan R M
University of Florida Health Science Center, Department of Pathology, Jacksonville 32209, USA.
Int J Gynecol Pathol. 1999 Jul;18(3):220-5.
From routine sign-out of endometrial biopsy specimens, a group of 15 endometria were identified that have a characteristic histologic pattern of inflammation that is not included in present classifications of endometritis. All but one of the women were premenopausal, and all presented with abnormal vaginal bleeding. The lesion is characterized by a patchy, focal inflammation, usually composed of lymphocytes with a variable number of neutrophils and rare macrophages centered around endometrial glands and extending into the glandular lumen with disruption and partial or subtotal necrosis of the endometrial glandular epithelium. These foci were widely dispersed, never confluent, and could be overlooked easily. Plasma cells were not found in any of the endometrial specimens despite methyl green pyronine staining of the samples. Based on the histologic characteristics of this process we have designated it focal necrotizing endometritis. The clinical significance, if any, of focal necrotizing endometritis is currently unknown.
在对子宫内膜活检标本进行常规病例讨论时，发现一组15例子宫内膜具有一种特征性的炎症组织学模式，目前的子宫内膜炎分类中并未包含该模式。除1名女性外，其他所有女性均处于绝经前，且均表现为异常阴道出血。该病变的特征为散在的局灶性炎症，通常由淋巴细胞组成，伴有数量不等的中性粒细胞，罕见巨噬细胞，以子宫内膜腺体为中心，延伸至腺管腔，导致子宫内膜腺上皮破坏及部分或全部坏死。这些病灶广泛分散，从不融合，很容易被忽视。尽管对样本进行了甲基绿派洛宁染色，但在任何子宫内膜标本中均未发现浆细胞。基于这一过程的组织学特征，我们将其命名为局灶性坏死性子宫内膜炎。目前尚不清楚局灶性坏死性子宫内膜炎是否具有临床意义。
