Hoerauf Achim, Adjei Ohene, Büttner Dietrich W
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Curr Opin Investig Drugs. 2002 Apr;3(4):533-7.
More effective drugs are needed for the treatment of human filarial diseases and the elimination of these infections as a public health problem. The drugs must either kill or sterilize adult worms. The relevant filariae, Onchocerca volvulus, Wuchereria bancofti and Brugia species, harbor rickettsial endoboacteria of the genus Wolbachia as symbionts. Animal experiments have shown that the elimination of these endobacteria causes inhibition of embryogenesis, and with Onchocerca ochengi a macrofilaricidal effect. Trials with human onchocerciasis patients using doxycydine demonstrated a long-term sterilizing activity, opening up a new strategy for the control of filarial infections. Indications of antiwolbachial therapy against onchocerciasis are discussed.
治疗人类丝虫病以及将这些感染作为公共卫生问题予以消除，需要更有效的药物。这些药物必须杀死成虫或使其绝育。相关的丝虫，如盘尾丝虫、班氏吴策线虫和布鲁线虫，都携带着沃尔巴克氏体属的立克次氏体内生细菌作为共生体。动物实验表明，消除这些内生细菌会抑制胚胎发育，对于奥氏奥氏丝虫还会产生杀大丝虫的作用。使用强力霉素对人类盘尾丝虫病患者进行的试验显示出长期的绝育活性，为控制丝虫感染开辟了新策略。本文讨论了抗沃尔巴克氏体疗法治疗盘尾丝虫病的指征。
