闪烁诱发的人类视神经血流变化：与视网膜神经活动的关系。

Flicker-evoked changes in human optic nerve blood flow: relationship with retinal neural activity.

作者信息

Falsini Benedetto, Riva Charles E, Logean Eric

机构信息

Institute of Ophthalmology, Catholic University of the Sacred Heart, Largo F. Vito 1, 00168 Rome, Italy.

出版信息

Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2309-16.

PMID:12091432

Abstract

PURPOSE

Visual flicker induces a response in human optic nerve blood flow (F(onh)) and inner retinal activity, as assessed by laser Doppler flowmetry and electroretinogram (ERG), respectively. In this study the relationship was examined between the flicker-evoked changes in F(onh) (RF(onh)) and ERG when various parameters of the stimulus were varied.

METHODS

In five normal observers (mean age, 41; range, 25-62 years) F(onh) and ERG were recorded simultaneously in response to pure red (R) or pure green (G) flicker, as well as heterochromatic R-G flicker (30 degrees field at the posterior pole). RF(onh) and the changes in the first (1F) and second (2F) harmonic amplitudes of the ERG were documented as a function of the frequency of pure luminance and equiluminant R-G flicker, the mean illuminance of 10-Hz luminance flicker, and the color ratio r = R/(R + G) of a 15-Hz heterochromatic R-G flicker.

RESULTS

Frequency-dependent changes in RF(onh) were similar to those in both 1F and 2F amplitudes for equiluminant R-G flicker. RF(onh) and 2F amplitude increased and then saturated with increasing mean illuminance of luminance flicker. They both decreased similarly as the R-G flicker approached the r value corresponding to equiluminance. RF(onh) was positively correlated with both 1F and 2F amplitudes (r = 0.55 and 0.31, respectively, P < 0.05) when these quantities were recorded as a function of frequency of R-G equiluminant flicker. RF(onh) was positively correlated with 2F amplitudes when both quantities were recorded as a function of mean illuminance of luminance flicker and r of heterochromatic R-G flicker (r = 0.52 and 0.48, respectively, P < or = 0.01).

CONCLUSIONS

Under specific experimental conditions, changes in human RF(onh) are similar to and correlated with those of the flicker ERG 1F and 2F amplitudes. These findings support a relationship between vaso- and neural activity changes in the neural tissue of the human eye.

摘要

目的

视觉闪烁会诱发人类视神经血流（F（onh））反应以及视网膜内层活动，分别通过激光多普勒血流仪和视网膜电图（ERG）进行评估。在本研究中，当刺激的各种参数变化时，研究了闪烁诱发的F（onh）变化（RF（onh））与ERG之间的关系。

方法

对五名正常观察者（平均年龄41岁；范围25 - 62岁），同时记录其对纯红色（R）或纯绿色（G）闪烁以及异色R - G闪烁（后极30度视野）的F（onh）和ERG。记录RF（onh）以及ERG的一次（1F）和二次（2F）谐波振幅变化，作为纯亮度和等亮度R - G闪烁频率、10赫兹亮度闪烁的平均照度以及15赫兹异色R - G闪烁的颜色比r = R /（R + G）的函数。

结果

对于等亮度R - G闪烁，RF（onh）的频率依赖性变化与1F和2F振幅的变化相似。随着亮度闪烁平均照度的增加，RF（onh）和2F振幅增加，然后达到饱和。当R - G闪烁接近对应等亮度的r值时，它们都以类似方式下降。当将这些量记录为R - G等亮度闪烁频率的函数时，RF（onh）与1F和2F振幅均呈正相关（分别为r = 0.55和0.31，P < 0.05）。当将这两个量记录为亮度闪烁平均照度和异色R - G闪烁r的函数时，RF（onh）与2F振幅呈正相关（分别为r = 0.52和0.48，P ≤ 0.01）。