Nakanishi N, Suzuki K, Tatara K
Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Japan.
Occup Med (Lond). 2002 Jun;52(4):213-8. doi: 10.1093/occmed/52.4.213.
We assessed the association of white blood cell (WBC) count with different components of metabolic syndrome (MS)-obesity, hypertension, hypercholesterolemia, low high-density lipoprotein cholesterol levels, hypertriglyceridemia, high fasting plasma glucose levels and hyperuricemia-in 5275 Japanese male office workers aged 23-59 years. After controlling for age, smoking and alcohol intake, the relative risks for the presence of 1, 2, 3, 4 and > or =5 features of MS compared with the lowest quintile of WBC count increased in a dose-dependent manner as WBC count increased (P for trend < 0.001 for all) and the increased relative risks for clustered features of MS were more pronounced as the number of features of MS increased. The WBC count increments in subjects with 1, 2, 3, 4 and > or =5 features of MS were 0.28, 0.45, 0.68, 0.76 and 1.40 x10(9) cells/l, respectively, compared with the subjects without features of MS (P for trend < 0.001). These findings indicate a strong association between WBC count and clustered features of MS in middle-aged Japanese men.
我们在5275名年龄在23至59岁的日本男性上班族中，评估了白细胞（WBC）计数与代谢综合征（MS）不同组分——肥胖、高血压、高胆固醇血症、低高密度脂蛋白胆固醇水平、高甘油三酯血症、高空腹血糖水平和高尿酸血症——之间的关联。在对年龄、吸烟和饮酒情况进行控制后，与白细胞计数最低五分位数相比，MS存在1、2、3、4及≥5种特征的相对风险随着白细胞计数增加呈剂量依赖性增加（所有趋势的P值均<0.001），且MS聚集特征的相对风险增加随着MS特征数量增加更为明显。与无MS特征的受试者相比，具有1、2、3、4及≥5种MS特征的受试者白细胞计数增量分别为0.28、0.45、0.68、0.76和1.40×10⁹个细胞/升（趋势P值<0.001）。这些发现表明中年日本男性白细胞计数与MS聚集特征之间存在密切关联。
