Vasunilashorn Sarinnapha
Office of Population Research, Princeton University, Princeton, NJ 08544, USA.
J Obes. 2013;2013:601534. doi: 10.1155/2013/601534. Epub 2013 Feb 11.
This study investigated the association between weight change and inflammation in a nationally representative population of US adults aged 40 and older.
Using the US National Health and Nutrition Examination Survey (2005-2008), logistic regression models were used to determine the relationship between high levels of inflammation (C-reactive protein [CRP]) and infection (white blood cell count [WBC]) with 1- and 10-year change in self-reported weight status.
Change in 1- and 10-year weight was associated with high CRP but not high WBC. Individuals who gained or lost ≥10 kg had an odds of having high CRP that was 1.96 (95% CI 1.11-3.50) and 1.61 (95% CI 1.02-2.46) as high, respectively, as those who maintained a stable weight (<4 kg change) in the past year. The increased risk of elevated CRP among individuals who experienced at least 10 kg of weight loss or weight gain was also observed for weight change that occurred over the past 10 years; however, weight loss over the 10-year period was no longer associated with high inflammation.
These results suggest that adult respondents who retrospectively self-reported weight loss or gain had higher levels of inflammation relative to their weight stable counterparts.
本研究调查了美国40岁及以上具有全国代表性的成年人群中体重变化与炎症之间的关联。
利用美国国家健康与营养检查调查（2005 - 2008年），采用逻辑回归模型来确定炎症水平升高（C反应蛋白[CRP]）和感染（白细胞计数[WBC]）与自我报告的体重状况1年和10年变化之间的关系。
1年和10年体重变化与高CRP相关，但与高WBC无关。在过去一年中，体重增加或减少≥10 kg的个体出现高CRP的几率分别是体重保持稳定（变化<4 kg）个体的1.96倍（95%置信区间1.11 - 3.50）和1.61倍（95%置信区间1.02 - 2.46）。在过去10年中发生体重变化的个体中，也观察到体重至少减轻或增加10 kg的个体CRP升高风险增加；然而，10年期体重减轻不再与高炎症相关。
这些结果表明，回顾性自我报告体重减轻或增加的成年受访者相对于体重稳定的受访者炎症水平更高。
