Frans A, Gerin-Portier N, Veriter C, Brasseur L
Scand J Respir Dis. 1975;56(5):233-44.
Pulmonary gas exchange has been studied in 14 healthy smokers and 16 healthy nonsmokers (mean age: 36 years) breathing hypoxic, normoxic and hyperoxic gas mixtures, in a sitting position, at rest and on exercise. Alveolar-arterial oxygen tension difference is increased in smokers in hypoxia, at rest and on exercise, and the pulmonary diffusing capacity for oxygen is decreased. In normoxia the alveolar-arterial oxygen tension difference is increased on exercise. There is no difference between the two groups in hyperoxia. For the whole group there exists a negative relationship between (A-a)DO2 in normoxia and the diffusion indices measured on exercise. Arterio-alveolar carbon dioxide tension difference and the ratio physiological dead space/tidal volume are almost identical in both groups in any condition. A diffusion defect seems to be the more constant alteration of gas exchange in asymptomatic smokers.
对14名健康吸烟者和16名健康非吸烟者（平均年龄：36岁）进行了肺气体交换研究，他们在静息和运动状态下，以坐姿呼吸低氧、常氧和高氧混合气体。吸烟者在低氧状态下静息和运动时，肺泡-动脉氧分压差增加，肺氧弥散能力下降。在常氧状态下，运动时肺泡-动脉氧分压差增加。两组在高氧状态下无差异。对于整个研究组，常氧状态下的（A-a）DO2与运动时测量的弥散指标之间存在负相关关系。在任何情况下，两组的动脉-肺泡二氧化碳分压差和生理死腔/潮气量比值几乎相同。在无症状吸烟者中，弥散缺陷似乎是气体交换中更持续存在的改变。
