Shetty Dhanashri N, Pathak Shubhangi S
Department of Biochemistry, L.T.M. Medical College, Sion, 508/B, Rajdeep, Opp. Sheetal Cinema, L.B.S. Marg, Kurla, Mumbai-400070, India.
J Reprod Med. 2002 Jun;47(6):494-6.
To correlate the levels of plasma neurotransmitters epinephrine, norepinephrine, serotonin and dopamine with memory in healthy, pregnant women.
Fifty healthy, pregnant women were selected in the first trimester and followed in the second and third trimesters of pregnancy. Nonpregnant women served as controls. Epinephrine, norepinephrine, serotonin and dopamine levels were analyzed with high-performance liquid chromatography. The plasma neurotransmitter levels were correlated with memory in each trimester of pregnancy.
Significant decreases (P < .001) in plasma epinephrine, serotonin and dopamine were observed in healthy, pregnant women in each trimester of pregnancy when compared to nonpregnant women. A significant increase in plasma norepinephrine was observed in healthy, pregnant women in each trimester of pregnancy. A significant decrease (P < .001) in functional memory was observed in healthy, pregnant women when compared to nonpregnant women.
Decreases in functional memory and of plasma epinephrine, norepinephrine and serotonin levels in the second trimester of healthy pregnancy suggests that decreased plasma neurotransmitter levels are responsible for loss of functional memory in healthy, pregnant women.
研究健康孕妇血浆中肾上腺素、去甲肾上腺素、血清素和多巴胺水平与记忆力之间的关系。
选取50名健康孕妇，在孕早期入选，并在孕中期和孕晚期进行跟踪观察。非孕妇作为对照。采用高效液相色谱法分析肾上腺素、去甲肾上腺素、血清素和多巴胺水平。分析孕期各阶段血浆神经递质水平与记忆力之间的关系。
与非孕妇相比，健康孕妇在孕期各阶段血浆肾上腺素、血清素和多巴胺水平显著降低（P < .001）。健康孕妇在孕期各阶段血浆去甲肾上腺素水平显著升高。与非孕妇相比，健康孕妇的功能性记忆力显著降低（P < .001）。
健康孕期第二阶段功能性记忆力以及血浆肾上腺素、去甲肾上腺素和血清素水平下降，提示血浆神经递质水平降低是导致健康孕妇功能性记忆力丧失的原因。
