Goenen M, Jaumin P, Raveau A, Tremouroux J
Scand J Thorac Cardiovasc Surg. 1975;9(3):206-11. doi: 10.3109/14017437509138641.
In order to study the haemodynamic effects of isoprenaline and glucagon in the immediate postoperative period, 16 patients who had single or multiple valve replacement or coronary artery bypass grafts were investigated. Measurements of cardiac index, stroke index, heart rate, arterial and right atrial mean pressures were made either before, during, or after the administration of both drugs. With the doses used, the inotropic effects of both drugs are similar, while the chronotropic action is statistically higher during isoprenaline infusion than after glucagon administration. This fact explains the greater increase in cardiac index after isoprenaline administration. Mean arterial pressure shows no significant changes after either drug, while right atrial mean pressure decreases significantly. Peripheral vascular resistance remained mostly constant. The activity of glucagon injected as a single bolus seems to be maximal 10 to 15 minutes after the injection and dissipates about 30 minutes later. The ideal dose of isoprenaline is between 0.8 and 2 mug/min. Within this range, the inotropic effect is maximal and the chronotropic and bathmotropic effects are limited. Above 2 mug/min, cardiac index and stroke index decrease, and arrhythmias become more frequent.
为研究异丙肾上腺素和胰高血糖素在术后即刻的血流动力学效应，对16例行单瓣膜或多瓣膜置换术或冠状动脉搭桥术的患者进行了研究。在给予两种药物之前、期间或之后，测量心指数、每搏指数、心率、动脉平均压和右心房平均压。在所使用的剂量下，两种药物的变力作用相似，而异丙肾上腺素输注期间的变时作用在统计学上高于给予胰高血糖素后。这一事实解释了给予异丙肾上腺素后心指数增加幅度更大的原因。两种药物给药后平均动脉压均无显著变化，而右心房平均压显著降低。外周血管阻力基本保持不变。单次推注胰高血糖素的活性在注射后10至15分钟似乎最大，并在约30分钟后消失。异丙肾上腺素的理想剂量为0.8至2微克/分钟。在此范围内，变力作用最大，变时作用和变传导作用受限。高于2微克/分钟时，心指数和每搏指数降低，心律失常变得更频繁。
