Ozkul Yasar, Gurler Bulent, Uckardes Ayla, Bozlar Senay
Faculty of Medicine, Department of Neurology, University of Harran, Sanliurfa, Turkey.
J Clin Neurosci. 2002 May;9(3):247-50. doi: 10.1054/jocn.2001.1015.
Gamma-aminobutyric acid-induced ion transport changes in the retinal pigment epithelium are described. Valproate acts as an inhibitor of gamma-aminobutyric acid transaminase. The purpose of this study was to investigate whether early visual impairment is related to valproate in patients with and without visual symptoms. Thirty-two patients, presenting with a history of seizures currently being treated with valproate, were included in the study. A complete clinical neuroophthalmologic examination was performed, including electroretinogram and visual field test. The electroretinogram parameters of epileptic patients were compared with those of 28 age- and sex-matched healthy volunteers. There was no significant difference in ERG parameters between the two groups. The visual field and visual acuity of all patients were within normal limits. When valproate is not used in conjunction with other antiepileptic drugs and serum levels are within therapeutic levels, it does not cause electrophysiologically detectable retinal dysfunction or any functional defect in visual perception that can be determined clinically.
描述了γ-氨基丁酸诱导的视网膜色素上皮细胞离子转运变化。丙戊酸盐作为γ-氨基丁酸转氨酶的抑制剂。本研究的目的是调查有或无视觉症状的患者早期视力损害是否与丙戊酸盐有关。本研究纳入了32例有癫痫病史且目前正在接受丙戊酸盐治疗的患者。进行了全面的临床神经眼科检查，包括视网膜电图和视野测试。将癫痫患者的视网膜电图参数与28名年龄和性别匹配的健康志愿者的参数进行比较。两组之间的视网膜电图参数无显著差异。所有患者的视野和视力均在正常范围内。当丙戊酸盐不与其他抗癫痫药物联合使用且血清水平在治疗范围内时，它不会引起电生理上可检测到的视网膜功能障碍或任何临床上可确定的视觉感知功能缺陷。
