Mochizuki Masami, Motoyoshi Megumi, Maeda Ken, Kai Kazunari
Laboratory of Clinical Microbiology, Kyoritsu Seiyaku Corporation, 1-12-4 Kudankita, Chiyoda-ku, Tokyo 102-0073, Japan.
Clin Diagn Lab Immunol. 2002 Jul;9(4):921-4. doi: 10.1128/cdli.9.4.921-924.2002.
The properties of neutralization of antigens of canine distemper virus Onderstepoort and a recent field isolate, KDK-1, were investigated with strain-specific dog sera. A conventional neutralization assay indicated antigenic dissimilarity between the strains; however, when guinea pig complement was included in the reaction mixture, the strains were neutralized with not only the homologous but also the heterologous antibodies.
用犬瘟热病毒翁德斯特普特株和最近分离的一株野外毒株KDK-1的抗原,与毒株特异性犬血清进行了中和特性研究。常规中和试验表明这些毒株之间存在抗原性差异;然而,当在反应混合物中加入豚鼠补体时,这些毒株不仅能用同源抗体中和,也能用异源抗体中和。