Tang Oi Shan, Xu Jieshuang, Cheng Linan, Lee Sharon W H, Ho Pak Chung
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong SAR, People's Republic of China.
Hum Reprod. 2002 Jul;17(7):1738-40. doi: 10.1093/humrep/17.7.1738.
A combination of mifepristone and misoprostol provides an effective method of medical abortion for early pregnancy. A new route of administration of misoprostol, the sublingual route, was investigated in this study.
One hundred women who requested legal termination of pregnancy up to 63 days were given 200 mg of oral mifepristone followed 48 h later by 800 microg (4 x 200 microg tablets) of sublingual misoprostol.
Ninety-four women (94%) had a complete abortion with this regimen. There was one ongoing pregnancy. The median duration of vaginal bleeding was 15 days. There were no serious complications. However, lower abdominal pain, diarrhoea, chills and fever were the commonest side-effects with incidences of 89, 42, 38 and 79% respectively.
The combination of mifepristone and sublingual misoprostol is effective for medical abortion up to 63 days gestation. Randomized trials are required to compare its efficacy and side-effect profile with vaginal misoprostol.
米非司酮与米索前列醇联合使用为早期妊娠提供了一种有效的药物流产方法。本研究对米索前列醇的一种新给药途径——舌下途径进行了研究。
100名要求合法终止妊娠且妊娠天数不超过63天的妇女口服200毫克米非司酮，48小时后舌下含服800微克（4片200微克的片剂）米索前列醇。
94名妇女（94%）采用该方案完全流产。有1例妊娠继续。阴道出血的中位持续时间为15天。无严重并发症。然而，下腹疼痛、腹泻、寒战和发热是最常见的副作用，发生率分别为89%、42%、38%和79%。
米非司酮与舌下含服米索前列醇联合使用对妊娠63天内的药物流产有效。需要进行随机试验以比较其与阴道用米索前列醇的疗效和副作用情况。
