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The therapeutic potential of modulating the ceramide/sphingomyelin pathway.

作者信息

Kolesnick Richard

机构信息

Laboratory of Signal Transduction, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

出版信息

J Clin Invest. 2002 Jul;110(1):3-8. doi: 10.1172/JCI16127.

DOI:10.1172/JCI16127
PMID:12093880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC151041/
Abstract
摘要

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本文引用的文献

1
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.1-磷酸鞘氨醇受体激动剂对淋巴细胞运输的改变
Science. 2002 Apr 12;296(5566):346-9. doi: 10.1126/science.1070238. Epub 2002 Mar 28.
2
Importance of C1B domain for lipid messenger-induced targeting of protein kinase C.C1B结构域对脂质信使诱导的蛋白激酶C靶向作用的重要性。
J Biol Chem. 2002 May 17;277(20):18037-45. doi: 10.1074/jbc.M111761200. Epub 2002 Mar 4.
3
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes.小鼠酸性神经酰胺酶基因的插入诱变导致纯合子早期胚胎致死和杂合子进行性脂质贮积病。
Genomics. 2002 Feb;79(2):218-24. doi: 10.1006/geno.2002.6686.
4
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes.膜筏在小鼠胸腺细胞中Fas/CD95触发的细胞死亡起始过程中的关键作用。
EMBO Rep. 2002 Feb;3(2):190-6. doi: 10.1093/embo-reports/kvf022. Epub 2002 Jan 29.
5
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.新生神经酰胺调节A549肺腺癌细胞中半胱天冬酶9和Bcl-x的可变剪接。对蛋白磷酸酶-1的依赖性。
J Biol Chem. 2002 Apr 12;277(15):12587-95. doi: 10.1074/jbc.M112010200. Epub 2002 Jan 18.
6
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR).Ras激酶抑制因子（KSR）富含半胱氨酸的C1结构域的溶液结构及功能分析
J Mol Biol. 2002 Jan 18;315(3):435-46. doi: 10.1006/jmbi.2001.5263.
7
Ceramide-rich membrane rafts mediate CD40 clustering.富含神经酰胺的膜筏介导CD40聚集。
J Immunol. 2002 Jan 1;168(1):298-307. doi: 10.4049/jimmunol.168.1.298.
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Molecular ordering of the initial signaling events of CD95.CD95初始信号事件的分子排序
Mol Cell Biol. 2002 Jan;22(1):207-20. doi: 10.1128/MCB.22.1.207-220.2002.
9
The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells.抗肿瘤醚脂ET-18-OCH(3)通过Fas/CD95在人白血病细胞中易位并聚集到膜筏中诱导细胞凋亡。
Blood. 2001 Dec 15;98(13):3860-3. doi: 10.1182/blood.v98.13.3860.
10
Lysophospholipids--receptor revelations.溶血磷脂——受体的新发现
Science. 2001 Nov 30;294(5548):1875-8. doi: 10.1126/science.1065323.