Nanayakkara N P Dhammika, Burandt Charles L, Jacob Melissa R
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Planta Med. 2002 Jun;68(6):519-22. doi: 10.1055/s-2002-32554.
Bioassay-guided fractionation of the ethyl acetate extract of the roots of Dalea scandens (Miller) R. Clausen var. paucifolia led to the isolation of new flavonoids, 2( S)-5'-(-1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2',4',5,7-tetrahydroxyflavanone, 2( S)-5'-(1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2'-methoxy-4',5,7-trihydroxyflavanone and 5'-(1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2',4',5,7-tetrahydroxyflavone. Structure elucidation was carried out by spectroscopic methods. All three compounds showed significant activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
对攀缘山蚂蝗（Miller）R. Clausen变种少叶山蚂蝗根的乙酸乙酯提取物进行生物测定导向的分级分离，得到了新的黄酮类化合物，2(S)-5'-(-1"',1"'-二甲基烯丙基)-8-(3",3"-二甲基烯丙基)-2',4',5,7-四羟基黄烷酮、2(S)-5'-(1"',1"'-二甲基烯丙基)-8-(3",3"-二甲基烯丙基)-2'-甲氧基-4',5,7-三羟基黄烷酮和5'-(1"',1"'-二甲基烯丙基)-8-(3",3"-二甲基烯丙基)-2',4',5,7-四羟基黄酮。通过光谱方法进行结构解析。所有三种化合物对甲氧西林敏感和耐甲氧西林金黄色葡萄球菌均表现出显著活性。
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