Jeong Seung-Il, Han Wan-Soo, Yun Yeon-Hee, Kim Kang-Ju
Wonkwang Biomaterial Implant Research Institute, Wonkwang University, Iksan City, Jeonbuk, Iksan, South Korea.
Phytother Res. 2006 Jun;20(6):511-4. doi: 10.1002/ptr.1894.
In a continuing search for compounds with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), a chloroform extract of roots of Aralia continentalis was found to contain continentalic acid (CA, C(20)H(30)O(2)), a diterpenic acid. This compound exhibited potent activity against standard methicillin-susceptible Staphylococcus aureus (MSSA) as well as clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). It was determined that continentalic acid had minimum inhibitory concentrations (MICs) of approximately 8-16 microg/mL against S. aureus, including the MSSA and MRSA standard strains. Therefore, the results obtained in this study suggest that continentalic acid might have potential as an adjunct in the treatment of antibiotic-resistant bacteria.
在持续寻找对耐甲氧西林金黄色葡萄球菌（MRSA）具有抗菌活性的化合物的过程中，发现辽东楤木根的氯仿提取物含有一种二萜酸——大陆酸（CA，C₂₀H₃₀O₂）。该化合物对标准的甲氧西林敏感金黄色葡萄球菌（MSSA）以及耐甲氧西林金黄色葡萄球菌（MRSA）的临床分离株均表现出强效活性。已确定大陆酸对金黄色葡萄球菌，包括MSSA和MRSA标准菌株的最低抑菌浓度（MIC）约为8 - 16微克/毫升。因此，本研究获得的结果表明大陆酸可能具有作为治疗抗生素耐药菌辅助药物的潜力。
