Mdegela R H, Msoffe P L M, Waihenya R W, Kasanga J C, Mtambo M M A, Minga U M, Olsen J E
Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, PO Box 3021, Morogoro, Tanzania.
Trop Anim Health Prod. 2002 May;34(3):195-204. doi: 10.1023/a:1015226507721.
The pathogenicity of a virulent strain of Salmonella gallinarum was studied in local chickens and commercial layers. Sixty 4-month-old chickens were used. Of these, 50 chickens were orally infected with S. gallinarum, comprising 25 commercial layers and 25 local chickens. Five chickens in each group were used as uninfected negative controls. The clinical signs and pathological features of acute, subacute and chronic fowl typhoid were observed in both groups. Chickens in both groups seroconverted, but the antibody titre was significantly higher (p < 0.001) in the commercial layers. The antibody titre remained high to the end of the experiment in all the surviving chickens. Only one commercial layer chicken died during the course of the experiment. The PCV decreased significantly (p < 0.001) in the infected chickens of both groups as compared to the controls. The viable cell count of S. gallinarum in the liver and spleen reached a maximum on day 9 after infection in both groups. However, there was a significantly higher cell count (p < 0.05) in the commercial layers. The severity of the disease appeared to be slightly greater in the commercial layers, although the susceptibility was similar in both groups. It was concluded that, under experimental conditions, local chickens are just as susceptible to S. gallinarum infection as are commercial layers.
对一株强毒鸡沙门氏菌在本地鸡和商品蛋鸡中的致病性进行了研究。使用了60只4月龄的鸡。其中，50只鸡经口感染鸡沙门氏菌，包括25只商品蛋鸡和25只本地鸡。每组5只鸡用作未感染的阴性对照。观察了两组鸡急性、亚急性和慢性禽伤寒的临床症状和病理特征。两组鸡均发生血清转化，但商品蛋鸡的抗体滴度显著更高（p<0.001）。在所有存活鸡中，抗体滴度在实验结束时仍保持较高水平。在实验过程中，只有1只商品蛋鸡死亡。与对照组相比，两组感染鸡的红细胞压积均显著降低（p<0.001）。两组鸡在感染后第9天肝脏和脾脏中的鸡沙门氏菌活菌数均达到最高值。然而，商品蛋鸡中的菌数显著更高（p<0.05）。尽管两组鸡的易感性相似，但商品蛋鸡的病情严重程度似乎略高。得出的结论是，在实验条件下，本地鸡对鸡沙门氏菌感染的易感性与商品蛋鸡相同。
