Kaaks Rudolf, Lukanova Annekatrin
International Agency for Research on Cancer, 69372 Lyon Cedex 08, France.
Ann N Y Acad Sci. 2002 Jun;963:268-81. doi: 10.1111/j.1749-6632.2002.tb04118.x.
Excess body weight and/or lack of physical activity are increasingly recognized as major risk factors for cancer of the colon, breast, endometrium, and prostate. This paper reviews the effects of excess body weight and physical inactivity on endogenous hormone metabolism (insulin, the IGF-I/IGFBP system, and sex steroids) and of endocrine alterations with risk of cancer of the endometrium, breast, prostate, and colon.
超重和/或缺乏体育活动日益被视为结肠癌、乳腺癌、子宫内膜癌和前列腺癌的主要风险因素。本文综述了超重和缺乏体育活动对内源性激素代谢（胰岛素、IGF-I/IGFBP系统和性激素）的影响，以及内分泌改变与子宫内膜癌、乳腺癌、前列腺癌和结肠癌风险的关系。
