Finelli Carmine, Tarantino Giovanni
Center of Obesity and Eating Disorder, Stella Maris Mediterraneo Foundation Chiaromonte, Potenza, Italy.
Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Naples, Italy.
Hepatol Int. 2013 Jun;7(2):413-28. doi: 10.1007/s12072-012-9406-z. Epub 2012 Oct 26.
Numerous epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome and its further expression, i.e., nonalcoholic fatty liver disease and death. Using novel models of visceral obesity, several studies have demonstrated that the relationship between visceral fat and longevity is causal, while the accrual of subcutaneous fat does not appear to play an important role in the etiology of disease risk. The need of reducing the visceral fat to improve survival, mainly taking into account the strict link between nonalcoholic fatty liver disease and the coronary artery disease is discussed.
众多流行病学研究表明，腹部肥胖是胰岛素抵抗、2型糖尿病、心血管疾病、中风、代谢综合征及其进一步表现（即非酒精性脂肪性肝病和死亡）的主要危险因素。通过使用新型内脏肥胖模型，多项研究已证明内脏脂肪与长寿之间的关系是因果关系，而皮下脂肪的积累在疾病风险的病因学中似乎并不起重要作用。本文讨论了减少内脏脂肪以提高生存率的必要性，主要考虑到非酒精性脂肪性肝病与冠状动脉疾病之间的紧密联系。
