Tsusaki H, Nishimura M, Kurebe M
Department of Toxicology, School of Veterinary Medicine, University of Osaka Prefecture, Japan.
J Toxicol Sci. 1995 Sep;20(4):395-400. doi: 10.2131/jts.20.4_395.
Effects of repeated s.c. treatments with 50 mumol (approx. 31 mg)/kg/day of neomycin for 10 or 15 days were examined in mice. There were no significant differences between saline and neomycin treatment groups in the motor coordination assessed by rota-rod test and traction test. On tension recordings, an in vitro addition of d-tubocurarine inhibited the twitch tensions evoked by the nerve stimulations in both cases of saline or neomycin treatment. Neomycin treatments shifted the concentration-response curve between twitch tension and d-tubocurarine to the left, dependently on its injection days. These results suggest that repeated treatments with neomycin enhance the inhibitory effect of d-tubocurarine on the neuromuscular transmission in mice without eliciting motor incoordination and muscle relaxation.
在小鼠中检测了连续10天或15天每天皮下注射50微摩尔（约31毫克）/千克新霉素的效果。在通过转棒试验和牵引试验评估的运动协调性方面，生理盐水组和新霉素治疗组之间没有显著差异。在张力记录中，体外添加d -筒箭毒碱在生理盐水或新霉素治疗的两种情况下均抑制了神经刺激诱发的抽搐张力。新霉素治疗使抽搐张力和d -筒箭毒碱之间的浓度 - 反应曲线向左移动，这取决于其注射天数。这些结果表明，重复给予新霉素可增强d -筒箭毒碱对小鼠神经肌肉传递的抑制作用，而不会引起运动不协调和肌肉松弛。
