关于腺苷高反应性在哮喘和慢性阻塞性肺疾病中的价值的不断演变的概念。
Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease.
作者信息
Polosa R, Rorke S, Holgate S T
机构信息
Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, Università di Catania, 95125 Catania, Italy.
出版信息
Thorax. 2002 Jul;57(7):649-54. doi: 10.1136/thorax.57.7.649.
Abstract
Adenosine is a purine nucleoside which mediates a variety of cellular responses relevant to asthma and COPD through interaction with specific receptors. Administration of adenosine by inhalation to patients with asthma and COPD is known to cause concentration related bronchoconstriction. Responses elicited by this purine derivative in asthma and COPD should not be considered as a mere reflection of non-specific airways hyperresponsiveness. Evaluation of airways responsiveness by adenosine induced bronchoconstriction may be valuable in differentiating asthma from COPD, monitoring of anti-inflammatory treatment in asthma, surveying disease progression, and assessing disease activity in relation to allergic airways inflammation.
摘要
腺苷是一种嘌呤核苷，它通过与特定受体相互作用介导多种与哮喘和慢性阻塞性肺疾病（COPD）相关的细胞反应。已知对哮喘和COPD患者进行吸入腺苷给药会引起浓度相关的支气管收缩。这种嘌呤衍生物在哮喘和COPD中引发的反应不应被视为仅仅是气道非特异性高反应性的反映。通过腺苷诱导的支气管收缩来评估气道反应性，对于区分哮喘与COPD、监测哮喘的抗炎治疗、观察疾病进展以及评估与过敏性气道炎症相关的疾病活动可能具有重要价值。
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