Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study.

Some chelating agents were examined for their ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate. Nitrilotriacetic acid (NTA), 1,2-cyclohexylenedinitrilotetraacetic acid (CDTA) and diethylenetriaminepentaacetic acid (DTPA) were extremely effective in vivo while CDTA and p-aminosalicylic acid (PAS) were efficient in vitro.