Pearson R G, Bhandari R, Quirk R A, Shakesheff K M
Tissue Engineering Group, School of Pharmaceutical Sciences, University of Nottingham, NG7 2RD, UK.
J Long Term Eff Med Implants. 2002;12(1):1-33.
Tissue formation within the body, as part of a development or repair process, is a complex event in which cell populations self-assemble into functional units. There is intense academic, medical, and commercial interest in finding methods of replicating these events outside the body. This interest has accelerated with the demonstration of the engineering of skin and cartilage tissue in the laboratory and there is now worldwide activity in the in vitro regeneration of tissues including nerve, liver, bone, heart valves, blood vessels, bladder, and kidney. Approaches to tissue engineering center on the need to provide signals to cell populations to promote cell proliferation and differentiation. This review considers recent advances in methods of providing these signals to cells using examples of progress in the engineering of complex tissues.
作为发育或修复过程的一部分，体内组织形成是一个复杂的过程，在此过程中细胞群体自我组装成功能单元。在体外复制这些过程的方法引起了学术界、医学界和商业界的浓厚兴趣。随着实验室中皮肤和软骨组织工程的成功展示，这种兴趣进一步升温，目前全球范围内都在开展包括神经、肝脏、骨骼、心脏瓣膜、血管、膀胱和肾脏等组织的体外再生研究。组织工程方法的核心是需要向细胞群体提供信号以促进细胞增殖和分化。本综述通过复杂组织工程进展的实例，探讨了向细胞提供这些信号的方法的最新进展。
