Leonora J, Tjäderhane L, Tieche J-M
Department of Physiology/Pharmacology, Risley Hall, School of Medicine, Loma Linda University, CA 92350, USA.
J Dent Res. 2002 Apr;81(4):259-64. doi: 10.1177/154405910208100407.
Previous studies have clearly established the down-regulating effect of a sucrose-rich diet on primary dentinogenesis in rat molars. Earlier observation of the negative effect of a high-sucrose diet on a parotid function involved in the control of intradentinal solute movement led us to hypothesize that parotid gland function(s) may have a role in regulating dentinogenesis. Dentin apposition in 1st and 2nd molars of young rats was measured by planimetry in sagittal sections. The following experimental variables were tested: standard and high-sucrose diets, removal of the parotid or the submandibular/sublingual glands, and diets in powder or pellet form. Removal of the submandibular/sublingual glands and changes in diet consistency did not significantly affect dentin apposition. Dentin apposition was significantly depressed by the high-sucrose diet or following parotidectomy. A further decrease followed the combination of the two treatments. Parotid glands appeared to exert a positive effect on dentin apposition in rat molars.
先前的研究已经明确证实了富含蔗糖的饮食对大鼠磨牙原发性牙本质形成的下调作用。早期观察到高糖饮食对参与控制牙本质内溶质移动的腮腺功能有负面影响，这使我们推测腮腺功能可能在调节牙本质形成中起作用。通过矢状切片的平面测量法来测定幼鼠第一和第二磨牙的牙本质沉积。测试了以下实验变量：标准饮食和高糖饮食、切除腮腺或下颌下腺/舌下腺，以及粉末状或颗粒状饮食。切除下颌下腺/舌下腺以及饮食稠度的变化对牙本质沉积没有显著影响。高糖饮食或腮腺切除术后，牙本质沉积显著减少。两种处理相结合后，牙本质沉积进一步减少。腮腺似乎对大鼠磨牙的牙本质沉积有积极作用。
