Samuni Yuval, Baum Bruce J
Department of Oral and Maxillofacial Surgery, Barzilai Medical Center, Ashkelon, Israel.
Biochim Biophys Acta. 2011 Nov;1812(11):1515-21. doi: 10.1016/j.bbadis.2011.06.014. Epub 2011 Jul 6.
In vivo gene delivery has long been seen as providing opportunities for the development of novel treatments for disorders refractory to existing therapies. Over the last two decades, salivary glands have proven to be a useful, if somewhat unconventional, target tissue for studying several potential clinical applications of therapeutic gene delivery. Herein, we follow the progress, address some problems and assess the outlook for clinical applications of salivary gland gene delivery. Our experience with these tissues provides a roadmap for the process of moving an idea from the laboratory bench to patients.
长期以来，体内基因递送一直被视为为现有疗法难以治愈的疾病开发新治疗方法提供了机会。在过去的二十年中，唾液腺已被证明是一种有用的（尽管有些非传统）靶组织，用于研究治疗性基因递送的几种潜在临床应用。在此，我们追踪其进展，解决一些问题，并评估唾液腺基因递送临床应用的前景。我们在这些组织方面的经验为将一个想法从实验室工作台转化为患者应用的过程提供了路线图。
