Noda M, Wataha J C, Kaga M, Lockwood P E, Volkmann K R, Sano H
Department of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University Graduate School of Dental Medicine, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Japan.
J Dent Res. 2002 Apr;81(4):265-9. doi: 10.1177/154405910208100408.
Few studies have investigated the ability of dental resins to induce cellular stress at sublethal concentrations. Cellular stress, especially in immune cells such as monocytes, may modulate the biological response to materials or the host's ability to respond to bacterially mediated inflammation. The current study examined the ability of sublethal concentrations of 2-hydroxylethylmethacrylate (HEMA) and triethyleneglycol dimethacrylate (TEGDMA) to induce heat shock protein 72 (HSP72) in human monocytes. HEMA and TEGDMA significantly suppressed heat-induced HSP72 expression, even at sublethal levels, but did not induce HSP72 by themselves. The results of the current study suggest that components released from dental resin could modulate the HSP stress response without altering cellular metabolic activity.
很少有研究调查牙科树脂在亚致死浓度下诱导细胞应激的能力。细胞应激，尤其是在单核细胞等免疫细胞中，可能会调节对材料的生物学反应或宿主对细菌介导的炎症的反应能力。本研究检测了亚致死浓度的甲基丙烯酸2-羟乙酯（HEMA）和二甲基丙烯酸三乙二醇酯（TEGDMA）诱导人单核细胞中热休克蛋白72（HSP72）的能力。HEMA和TEGDMA即使在亚致死水平也能显著抑制热诱导的HSP72表达，但它们自身不会诱导HSP72。本研究结果表明，牙科树脂释放的成分可以调节HSP应激反应，而不改变细胞代谢活性。
