Ionescu Roxana Nicoleta, Totan Alexandra Ripszky, Imre Marina Meleșcanu, Țâncu Ana Maria Cristina, Pantea Mihaela, Butucescu Mihai, Farcașiu Alexandru Titus
Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 17-23 Plevnei Street, 020021 Bucharest, Romania.
The Interdisciplinary Center for Dental Research and Development, Department of Biochemistry, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 17-23 Plevnei Street, 020021 Bucharest, Romania.
Materials (Basel). 2022 Jan 28;15(3):1016. doi: 10.3390/ma15031016.
The purpose of this study is to outline relevant elements regarding the biochemical interactions between prosthetic materials used for obtaining implant-supported restorations and the oral environment. Implant-supported prostheses have seen unprecedented development in recent years, benefiting from the emergence of both new prosthetic materials (with increased biocompatibility and very good mechanical behavior), and computerized manufacturing technologies, which offer predictability, accuracy, and reproducibility. On the other hand, the quality of conventional materials for obtaining implant-supported prostheses is acknowledged, as they have already proven their clinical performance. The properties of PMMA (poly (methyl methacrylate))-which is a representative interim material frequently used in prosthodontics-and of PEEK (polyether ether ketone)-a biomaterial which is placed on the border between interim and final prosthetic use-are highlighted in order to illustrate the complex way these materials interact with the oral environment. In regard to definitive prosthetic materials used for obtaining implant-supported prostheses, emphasis is placed on zirconia-based ceramics. Zirconia exhibits several distinctive advantages (excellent aesthetics, good mechanical behavior, biocompatibility), through which its clinical applicability has become increasingly wide. Zirconia's interaction with the oral environment (fibroblasts, osteoblasts, dental pulp cells, macrophages) is presented in a relevant synthesis, thus revealing its good biocompatibility.
本研究的目的是概述与用于获得种植体支持修复体的修复材料和口腔环境之间生化相互作用相关的要素。近年来，种植体支持的修复体取得了前所未有的发展，这得益于新型修复材料（生物相容性增强且机械性能良好）的出现以及计算机化制造技术的发展，这些技术提供了可预测性、准确性和可重复性。另一方面，用于获得种植体支持修复体的传统材料的质量是有目共睹的，因为它们已经证明了自己的临床性能。为了说明这些材料与口腔环境相互作用的复杂方式，重点介绍了聚甲基丙烯酸甲酯（PMMA）（口腔修复学中常用的一种代表性临时材料）和聚醚醚酮（PEEK）（一种介于临时和最终修复用途之间的生物材料）的特性。对于用于获得种植体支持修复体的确定性修复材料，重点介绍了氧化锆基陶瓷。氧化锆具有几个显著优点（美学效果极佳、机械性能良好、生物相容性好），凭借这些优点，其临床适用性越来越广泛。文中以相关综述的形式介绍了氧化锆与口腔环境（成纤维细胞、成骨细胞、牙髓细胞、巨噬细胞）的相互作用，从而揭示了其良好的生物相容性。
